MSD, V116 Project

DPS was awarded the BoD and EPCMV aspects for a major upgrade at MSD, Brinny facility, to provide vaccine production capability with alterations and extensions to a permitted pharmaceutical production building, for pharmaceutical vaccine production use.

Location: Ireland
Sector: Biopharmaceutical

About This Project

The works included a new first floor, internal works, the alteration of all elevations, construction of a new 2 storey extension to the west elevation and to the east elevation.
The works also included the demolition of an existing steel pipe-rack to the north and east elevations. 
The existing facility is approx. 4,000m².
Dual production trains provided within the existing first floor of the two storey facility, based on a Single Use Philosophy.
Warehouse, staging, cold storage and freezer capability were also being provided for material accommodation.
Office and personnel ‘pods’ provided within the building as it is standalone from the main MSD campus. 
Key design aspects allow multi-product use (material handling to OEB4 containment levels), and DCS control system.
A significant element of the installation was modular, including main racks (PARs), CSR/MCC rooms, changing rooms and equipment skids.

Major Process Equipment Items

  • Single Use Technology (SUMs, SUBs, Bags)
  • 2 no. Lyo Units
  • 2 no. Autoclaves
  • 2 no. Parts Washer Units
  • New WFI Still, Storage & Distribution
  • Glovebox Charging 
  • WFI, Clean Steam, LPHW, CIP Services
  • Heating / Cooling Skid(s)
  • Mobile Vessels 
  • Utility Manifolds & Interconnections
  • Delta V Control System
  • Buffer Preparation and Staging
  • Warehouse Staging (including Cold Room and -70°C Freezer)
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