Homology, Viral Vector Manufacturing Facility & QC Operations

To support its rapid transition into clinical development, the client is planning to build a new cGMP Manufacturing/ Pilot and QC Operations facility.

Location: Massachusetts
Sector: Gene Therapy

About This Project

This genetic medicines company translates proprietary gene editing and gene therapy technologies into novel treatments for patients to cure genetic diseases. This project comprises a self-contained, small-scale cGMP viral vector manufacturing operation within a build-out of 15,000SF.

The facility design includes all supporting utilities, infrastructure and services, including QC labs, to support a phase 1/2 manufacturing operation within a shell space. DPS provided full architectural and engineering design services for the new facility in partnership with a design build, construction management firm.

Project Scope

The facility includes the following:

  • cGMP Manufacturing space
  • QC Labs 
  • Loading dock and warehouse to support both cGMP and general operations
  • Utilities to support facility operations (GMP MFP, QC Labs, Warehouse)

The primary manufacturing areas comprises two upstream cell culture suites, two downstream purification suites, and inoculum/seed space to feed cell culture suites. The design needed to accommodate the capacity to exchange equipment/skids within each suite without major disruptions.

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